How community-based groups are confronting and preventing alcohol and other drug problems and related crime in their communities is the focus of this publication. A wide range of approaches and strategies, used by 10 nonprofit, community-based organizations representative of urban and rural areas, are presented. Case studies describe two community associations that mobilized residents to rid their neighborhoods of illegal drug activity. Three projects are highlighted that demonstrate the importance of developing partnerships and coalitions with a variety of community groups, building on the work of existing networks. Two case studies illustrate a comprehensive community development approach to prevention that includes providing prevention, intervention and treatment services along with decent and affordable housing, clean and safe streets and parks, opportunities and jobs for youth, and accessible social services. Finally, three case studies show how community-based organizations counter risk factors confronting youth through activities that provide employment training, academic assistance, education in life skills, and enhancement of cultural knowledge. Contact information follows each case study. A resource guide provides information on: technical assistance providers, selected publications, information clearinghouses, and funding opportunities. (JBJ)