This article describes a chemistry/art activity that originated in an National Science Foundation--funded two-week STEAM (Science, Technology, Engineering, Art, and Math) academy for grade 4-6 girls. The authors recommend using this investigation in conjunction with other activities focusing on chemical change as a step toward fulfilling the "Next Generation Science Standards" ("NGSS") performance expectation 5-PS1-4: "Conduct an investigation to determine whether the mixing of two or more substances results in new substances" (NGSS Lead States 2013). The investigation leverages the overlapping practices of art and science, including observation, experimentation, and the creation of solutions to design problems, as students use chemical reactions to develop a multicolored palette for painting. Using acids and bases to change the color of red cabbage pigments, students explore the disciplinary core idea that mixing substances can result in chemical reactions that form new substances with different properties.