The National Center for Leadership in Intensive Intervention (NCLII), a consortium funded by the Office of Special Education Programs (OSEP), prepares special education leaders to become experts in research on intensive intervention for students with disabilities who have persistent and severe academic (e.g., reading and math) and behavioral difficulties. By the end of the first year of their program, scholars in each cohort work in cross-institutional collaborative groups to create an Intensive Intervention Practice Guide. In each guide, scholars identify an approach to intensive intervention for a select population of students with disabilities, describe the existing evidence base behind it, and discuss the next steps in research needed to improve the understanding of designing and delivering the intervention. The "Intensive Intervention Practice Guides" are created for practitioners as well as faculty engaged in instructing pre- and in-service teachers. This practice guide discusses Check-In Check-Out (CICO), or the Behavioral Education Program (BEP), which is one example of a targeted (i.e., Tier 2) intervention used within a system of school-wide positive behavior supports (SWPBS). CICO was designed to reduce the frequency and severity of problem behavior among students who did not respond to Tier 1 interventions. Due to the nature of the procedural components and continual access to teachers and monitors, CICO has been most successful for students with problem behavior maintained by adult attention. Two cornerstones of CICO are adult attention and feedback, which are integrated throughout CICO procedures. Generally speaking, intensified CICO has taken the form of "dosage" increases, modifications to standard components, or supplemental targeted components. Overall, standard protocol Tier 2 CICO appears to be an effective program for reducing rates of problem behaviors and is easily intensified for students who are nonresponsive. The guide includes a list of resources.