Federal education funding has often been overlooked by districts in search of sources of support for prevention. This guide is intended to help school districts take advantage of those funds by identifying K-12 grant programs in the U.S. Department of Education (ED) that could be used to implement prevention efforts in elementary and secondary schools. The Center for Health and Health Care in Schools and the Center on Education Policy, both at the George Washington University, analyzed dozens of federally funded programs administered by ED. This research found 15 specific funded programs that contain either explicit or implicit authority for prevention-related activities. The main sections of this guide describe each of these programs, including their purpose, recent funding levels, entities eligible for funding, and specific provisions in the authorizing legislation, regulations, or program guidance that explicitly or implicitly permit funds to be used for prevention. The majority of these programs are part of the Elementary and Secondary Education Act of 1965 (ESEA), which was most recently amended in 2002 by the No Child Left Behind Act. Although ESEA is overdue for reauthorization, Congress continues to appropriate funds for these programs. This guide contains recommendations to be used while exploring the options related to funding opportunities, as well as suggestions for successful approaches to the application process.