The present qualitative study was conducted in response to federal initiatives aimed at increasing the number of science, technology, engineering, and mathematics (STEM) schools in the United States; and to better understand STEM high school administrators', teachers', and students' perceptions of the characteristics of the curricular and instructional strategies and practices representative of their schools. Six STEM high schools with diverse organizational models were purposively selected to represent varied geographical regions, socioeconomic and ethnic groups, and levels of entrance criteria. During 2-day site visits at each school, administrators, teachers, and students were interviewed. Three themes emerged from the data analysis: (a) a common vision of a challenging and engaging learning environment, (b) a focus on applying curricular and instructional strategies and practices to real-world problems, and (c) an appreciation for academic and affective support in the challenging learning environment. Interested stakeholders might discover strategies and practices to support their respective missions.