The role of the university in society and the economy is evolving. Universities produce knowledge that promotes technological developments, which are, in turn, critical to economic growth and competitiveness in the global economy. Therefore, it is increasingly expected that universities become more entrepreneurial and assume this third mission in order to promote innovation and development through the provision of technologies and business ventures. Drawing on data collected for The Changing Academic Profession Project--a comparative survey of the academic profession carried out in 19 countries from all over the world--this article explores Portuguese academic entrepreneurship engagement based on the involvement in the process of technology transfer as an activity performed in the context of research activities. It thus aims to contribute to knowledge about academics' engagement in entrepreneurial activity. Results from this study suggest that Portuguese academics are fairly involved in entrepreneurial activities and that there is an overall positive attitude towards application of research to real problems. Furthermore, it was possible to see that academics involved in processes of technology transfer are not only focused on activities such as research but also service to the outside community. However, when comparing academics involved and not involved in entrepreneurial activities, several significant differences are found in their attitudes, perceptions and behaviours.