Enrollment in Advanced Placement (AP) courses and performance on Advanced Placement examinations for American Indians in the U.S. for 2007 was analyzed. Scores on AP examinations, overall and then for five AP courses, were compared to the AP examination scores of White students. In every case, American Indians had AP examination scores that were significantly and practically lower than the scores of White students. American Indian female students had AP examination scores that were lower than the examination scores of White female students. Similar findings were present for male students. Implications of these findings are discussed. (Contains 10 tables.)