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ERIC Number: EJ998964
Record Type: Journal
Publication Date: 2012-Jun
Pages: 5
Abstractor: As Provided
Reference Count: 26
ISSN: ISSN-0021-9584
Use of a Spreadsheet to Help Students Understand the Origin of the Empirical Equation that Allows Estimation of the Extinction Coefficients of Proteins
Sims, Paul A.
Journal of Chemical Education, v89 n6 p738-742 Jun 2012
A brief history of the development of the empirical equation that is used by prominent, Internet-based programs to estimate (or calculate) the extinction coefficients of proteins is presented. In addition, an overview of a series of related assignments designed to help students understand the origin of the empirical equation is provided. The assignments culminate in a challenge whereby students were encouraged to develop a similar equation. The results of a student survey suggest that the assignments helped increase understanding of how the empirical equation was developed, in particular, and of the use of statistical methods (e.g., multiple linear regression, nonlinear least-squares fitting), in general. (Contains 2 tables and 1 figure.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A