Children with autism may not develop safety skills (e.g., help-seeking behaviors) without explicit teaching. One potentially hazardous situation is when a child with autism becomes separated from caregivers in a retail establishment or other public setting. The purpose of this study was to evaluate a treatment package (rules, role playing, and praise) delivered in the natural environment for teaching 3 boys with autism to seek assistance from store employees when they became lost. Treatment was effective, and help-seeking behaviors generalized to untrained stores for all participants. (Contains 1 figure.)