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ERIC Number: EJ980427
Record Type: Journal
Publication Date: 2012-Mar
Pages: 11
Abstractor: As Provided
Reference Count: 44
ISSN: ISSN-0022-5002
Effects of Acute and Chronic Cocaine Administration on Titrating-Delay Matching-to-Sample Performance
Kangas, Brian D.; Branch, Marc N.
Journal of the Experimental Analysis of Behavior, v97 n2 p151-161 Mar 2012
The effects of cocaine were examined under a titrating-delay matching-to-sample procedure. In this procedure, the delay between sample stimulus offset and comparison stimuli onset adjusts as a function of the subject's performance. Specifically, matches increase the delay and mismatches decrease the delay. Titrated delay values served as the primary dependent measure. After establishing stable performance in pigeons, several behaviorally-effective doses of cocaine were administered acutely. Dose-related within-session decreases in titrated delay values were observed. Following acute determinations, the dose of cocaine that produced the most rapid decline without eliminating performance was administered prior to each daily session. Chronic administration resulted in performance trending toward control levels. A redetermination of the dose-response function following chronic exposure revealed reduced potency (i.e., tolerance) under cocaine on titrated delay matching-to-sample performance. Supplemental analyses suggest that cocaine may serve as a disruptor of the stimulus conditions in which the performance was established. (Contains 5 figures.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A