This special issue, Developing Social- Emotional and Behavioral Interventions with School Communities: Systematic and Collaborative Processes, reflects the current state of the science for improving schools to better educate children and adolescents and promote their behavioral health. The innovations described in this volume describe advancements in intervention programs and in implementation and school change at a broader level. After briefly commenting about the contributions to this special issue, I go on to suggest ways to expand the focus of our science to innovate more effective school systems. In doing so, I touch on lessons learned by our research group as we collaborated with public school systems during the past 20 years. (Contains 2 figures.)