Program effectiveness reviews in education seek to provide educators with scientifically valid and useful summaries of evidence on achievement effects of various interventions. Different reviewers have different policies on measures of content taught in the experimental group but not the control group, called here "treatment-inherent" measures. These are contrasted with "treatment-independent" measures of content emphasized equally in experimental and control groups. The What Works Clearinghouse (WWC) averages effect sizes from such measures with those from treatment-independent measures, while the Best Evidence Encyclopedia excludes treatment-inherent measures. This article contrasts effect sizes from treatment-inherent and treatment-independent measures in WWC reading and math reviews to explore the degree to which these measures produce different estimates. In all comparisons, treatment-inherent measures produce much larger positive effect sizes than treatment-independent measures. Based on these findings, it is suggested that program effectiveness reviews exclude treatment-inherent measures, or at least report them separately. (Contains 2 tables.)