ERIC Number: EJ951217
Record Type: Journal
Publication Date: 2012-Jan
Abstractor: As Provided
Reference Count: 60
Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder
Corrigan, Neva M.; Shaw, Dennis. W. W.; Richards, Todd L.; Estes, Annette M.; Friedman, Seth D.; Petropoulos, Helen; Artru, Alan A.; Dager, Stephen R.
Journal of Autism and Developmental Disorders, v42 n1 p105-115 Jan 2012
Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ([superscript 1]HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3-4, 6-7 and 9-10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. [superscript 1]HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship.
Descriptors: Evidence, Autism, Etiology, Brain Hemisphere Functions, Developmental Delays, Diagnostic Tests, Pervasive Developmental Disorders, Longitudinal Studies, Children, Case Studies, Role, Symptoms (Individual Disorders), Therapy, Spectroscopy
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A