ERIC Number: EJ951022
Record Type: Journal
Publication Date: 2011-Dec
Abstractor: As Provided
Reference Count: 0
Anterior Thalamic Lesions Alter Both Hippocampal-Dependent Behavior and Hippocampal Acetylcholine Release in the Rat
Savage, Lisa M.; Hall, Joseph M.; Vetreno, Ryan P.
Learning & Memory, v18 n12 p751-758 Dec 2011
The anterior thalamic nuclei (ATN) are important for learning and memory as damage to this region produces a persistent amnestic syndrome. Dense connections between the ATN and the hippocampus exist, and importantly, damage to the ATN can impair hippocampal functioning. Acetylcholine (ACh) is a key neurotransmitter in the hippocampus, and in vivo measures of ACh are correlated to learning and memory performance. In the present study, complete lesions of the ATN impaired performance on two measures of hippocampal-dependent learning and memory (spontaneous alternation and delayed alternation) and severely disrupted behaviorally evoked ACh efflux within the hippocampus of adult male rats. In contrast, incomplete ATN lesions did not impair spontaneous alternation performance but did impair delayed alternation performance while blunting hippocampal ACh efflux. Interestingly, ATN lesions of any size did not affect basal concentrations of ACh in the hippocampus. These results demonstrate that the ATN have the capacity to modulate behaviorally relevant neuronal transmission within the hippocampus.
Descriptors: Learning, Memory, Brain, Neurological Impairments, Correlation, Animals, Males, Animal Behavior, Biochemistry
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A