ERIC Number: EJ949983
Record Type: Journal
Publication Date: 2006-Nov
Abstractor: As Provided
Reference Count: 0
Increased Error-Related Negativity (ERN) in Childhood Anxiety Disorders: ERP and Source Localization
Ladouceur, Cecile D.; Dahl, Ronald E.; Birmaher, Boris; Axelson, David A.; Ryan, Neal D.
Journal of Child Psychology and Psychiatry, v47 n10 p1073-1082 Nov 2006
Background: In this study we used event-related potentials (ERPs) and source localization analyses to track the time course of neural activity underlying response monitoring in children diagnosed with an anxiety disorder compared to age-matched low-risk normal controls. Methods: High-density ERPs were examined following errors on a flanker task from 12 children between 8 and 14 years old diagnosed with an anxiety disorder (ANX) and 13 age-matched low-risk normal controls (LRNC). Results: Children diagnosed with an anxiety disorder had increased error-related negativity (ERN) amplitude. The neural generators of the ERN in the ANX group were estimated to be localized in the anterior cingulate cortex (ACC). There were no significant group differences in P[subscript E] amplitude. Conclusions: These data provide evidence for increased ERN amplitude localized to the ACC in children diagnosed with an anxiety disorder, suggesting altered maturational patterns of the ACC circuitry early in the course of this illness.
Descriptors: Evidence, Anxiety Disorders, Anxiety, Diagnostic Tests, Brain Hemisphere Functions, Clinical Diagnosis, Control Groups, Children, Error Patterns, Developmental Stages, Child Development
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A