ERIC Number: EJ949979
Record Type: Journal
Publication Date: 2006-Nov
Abstractor: As Provided
Reference Count: 0
Reward-Related Decision-Making in Pediatric Major Depressive Disorder: An fMRI Study
Forbes, Erika E.; Christopher May, J.; Siegle, Greg J.; Ladouceur, Cecile D.; Ryan, Neal D.; Carter, Cameron S.; Birmaher, Boris; Axelson, David A.; Dahl, Ronald E.
Journal of Child Psychology and Psychiatry, v47 n10 p1031-1040 Nov 2006
Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9-17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing.
Descriptors: Anxiety Disorders, Brain, Rewards, Probability, Depression (Psychology), Anxiety, Decision Making, Children, Diagnostic Tests, Affective Behavior, Responses, Neurological Organization, Adolescents
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
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