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ERIC Number: EJ948218
Record Type: Journal
Publication Date: 2011-Nov
Pages: 10
Abstractor: As Provided
Reference Count: 39
ISSN: ISSN-1087-0547
Association among SNAP-25 Gene "Dd"eI and "Mnl"I Polymorphisms and Hemodynamic Changes during Methylphenidate Use: A Functional Near-Infrared Spectroscopy Study
Oner, Ozgur; Akin, Ata; Herken, Hasan; Erdal, Mehmet Emin; Ciftci, Koray; Ay, Mustafa Ertan; Bicer, Duygu; Oncu, Bedriye; Bozkurt, Ozlem Hekim; Munir, Kerim; Yazgan, Yanki
Journal of Attention Disorders, v15 n8 p628-637 Nov 2011
Objective: To investigate the interaction of treatment-related hemodynamic changes with genotype status for Synaptosomal associated protein 25 (SNAP-25) gene in participants with attention deficit hyperactivity disorder (ADHD) on and off single dose short-acting methylphenidate treatment with functional near-infrared spectroscopy (fNIRS). Method: A total of 15 right-handed adults and 16 right-handed children with "DSM-IV" diagnosis of ADHD were evaluated. Ten milligrams of short-acting methylphenidate was administered in a crossover design. Results: Participants with SNAP-25 "Dd"eI T/T genotype had decreased right deoxyhemoglobin ([HHb]) with treatment. SNAP-25 "Mnl"I genotype was also associated with right deoxyhemoglobin ([HbO2]) and [HHb] changes as well as left [HHb] change. When the combinations of these genotypes were taken into account, the participants with ["Dd"eI C/C or T/C and "Mnl"I G/G or T/G] genotype had increased right [HHb] with MPH use whereas the participants with ["Dd"eI T/T and "Mnl"I T/T] or ["Dd"eI T/T and "Mnl"I G/G or T/G] genotypes had decreased right prefrontal [HHb]. Conclusions: These results suggested that SNAP-25 polymorphism might be associated with methylphenidate induced brain hemodynamic changes in ADHD participants. (Contains 1 table and 4 figures.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A