NotesFAQContact Us
Search Tips
Peer reviewed Peer reviewed
Direct linkDirect link
ERIC Number: EJ945164
Record Type: Journal
Publication Date: 2006-Jul
Pages: 8
Abstractor: As Provided
Reference Count: 0
ISSN: ISSN-0890-8567
Elevated Childhood Serotonergic Function Protects against Adolescent Aggression in Disruptive Boys
Halperin, Jeffrey M.; Kalmar, Jessica H.; Schulz, Kurt P.; Marks, David J.; Sharma, Vanshdeep; Newcorn, Jeffrey H.
Journal of the American Academy of Child & Adolescent Psychiatry, v45 n7 p833-840 Jul 2006
Objective: This longitudinal study examined whether responsiveness of the neurotransmitter serotonin (5-HT) in childhood predicts adolescent aggression. Method: Boys (N = 33) with disruptive behavior disorders who received assessments of central 5-HT function via the prolactin response to fenfluramine between 1990 and 1994 when they were 7 to 11 years old were re-evaluated clinically on average 6.7 years later. Results: After accounting for baseline aggression, early 5-HT function accounted for a significant proportion of variance in adolescent aggression. This prospective relationship of childhood 5-HT function with adolescent aggression (r = -0.71) and antisocial behavior (r = -0.59) was found primarily in adolescents who were aggressive during childhood. Irrespective of childhood aggression, no child with high 5-HT function was particularly aggressive at follow-up. Conclusions: Low childhood 5-HT function appears important, but not sufficient, for the emergence of adolescent aggression. However, early high 5-HT function may protect against adolescent violence and aggression. (Contains 2 figures and 2 tables.)
Elsevier. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Tel: 877-839-7126; Tel: 407-345-4020; Fax: 407-363-1354; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A