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ERIC Number: EJ944059
Record Type: Journal
Publication Date: 2011-Nov
Pages: 9
Abstractor: As Provided
Reference Count: 72
ISBN: N/A
ISSN: ISSN-0162-3257
Is Neonatal Jaundice Associated with Autism Spectrum Disorders: A Systematic Review
Amin, Sanjiv B.; Smith, Tristram; Wang, Hongyue
Journal of Autism and Developmental Disorders, v41 n11 p1455-1463 Nov 2011
Using guidelines of the Meta-analysis of Observational Studies in Epidemiology Group, we systematically reviewed the literature on neonatal jaundice (unconjugated hyperbilirubinemia) and Autism Spectrum Disorder (ASD) in term and preterm infants. Thirteen studies were included in a meta-analysis. Most used retrospective matched case-control designs. There was significant heterogeneity (Q = 31, p = 0.002) and no evidence of publication bias (p = 0.12). Overall, jaundice, assessed by total serum bilirubin (TSB), was associated with ASD (OR, 1.43, 95% CI 1.22-1.67, random effect model). This association was not found in preterms (OR 0.7, 95% CI 0.38-1.02) but deserves further investigation since other measures of bilirubin such as unbound unconjugated bilirubin may be better predictors of neurotoxicity than TSB in preterms.
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Publication Type: Information Analyses; Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A