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ERIC Number: EJ943636
Record Type: Journal
Publication Date: 2011-Sep
Pages: 6
Abstractor: As Provided
Reference Count: 29
ISBN: N/A
ISSN: ISSN-0021-9584
A Simple Spreadsheet Program to Simulate and Analyze the Far-UV Circular Dichroism Spectra of Proteins
Abriata, Luciano A.
Journal of Chemical Education, v88 n9 p1268-1273 Sep 2011
A simple algorithm was implemented in a spreadsheet program to simulate the circular dichroism spectra of proteins from their secondary structure content and to fit [alpha]-helix, [beta]-sheet, and random coil contents from experimental far-UV circular dichroism spectra. The physical basis of the method is briefly reviewed within the context of protein structure, and the mathematical aspects of the approach are given together with ready-to-use code and examples. The work illustrates the use of simple yet powerful programming tools for simulations and data analysis in class and provides a means to explore the circular dichroism spectra of proteins and the applications of this spectroscopic technique to the study of proteins. (Contains 2 tables and 4 figures.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A