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ERIC Number: EJ941617
Record Type: Journal
Publication Date: 2011-Oct
Pages: 10
Abstractor: As Provided
Reference Count: 0
ISSN: ISSN-0890-8567
Progression of Amygdala Volumetric Abnormalities in Adolescents after Their First Manic Episode
Bitter, Samantha M.; Mills, Neil P.; Adler, Caleb M.; Strakowski, Stephen M.; DelBello, Melissa P.
Journal of the American Academy of Child & Adolescent Psychiatry, v50 n10 p1017-1026 Oct 2011
Objective: Although previous neuroimaging studies suggest that adolescents with bipolar disorder exhibit smaller amygdala volumes compared with healthy adolescents, whether these abnormalities are present at illness onset or instead develop over time remains unclear. The aim of this study was to conduct a prospective longitudinal investigation comparing amygdala neurodevelopment among adolescents after their first manic episode, adolescents with attention-deficit/hyperactivity disorder (ADHD), and healthy adolescents. Method: A total of 30 adolescents hospitalized for their first manic/mixed episode associated with bipolar disorder, 29 adolescents with ADHD, and 24 demographically matched healthy teens underwent magnetic resonance imaging scanning at index assessment and approximately 12 months later. Adolescents with bipolar disorder were prospectively evaluated using diagnostic interviews and with symptom rating scales. Results: Mixed models examining the group x time effect for both left (p = 0.005) and right (p = 0.002) amygdala volumes were statistically significant. Change in left (p = 0.01) and right (p = 0.0008) amygdala volumes from baseline to 12 months were significantly different among groups. Specifically, left amygdala volumes increased over time in healthy adolescents (p = .008) and adolescents with ADHD (p = 0.0009), but not in adolescents with bipolar disorder (p = 0.3). Right amygdala volume increased over time in adolescents with ADHD (p less than 0.001), but not in healthy adolescents nor in adolescents with bipolar disorder (p = 0.1 and p = 0.3, respectively). In adolescents with bipolar disorder, baseline total amygdala volume was significantly greater in those who subsequently achieved symptomatic recovery as compared with those who did not achieve recovery (p = 0.02). Conclusions: Adolescents with mania do not exhibit normal increases in amygdala volume that occur during healthy adolescent neurodevelopment. (Contains 2 tables and 3 figures.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A