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ERIC Number: EJ939016
Record Type: Journal
Publication Date: 2011-Jul
Pages: 3
Abstractor: As Provided
Reference Count: 4
ISSN: ISSN-0021-9584
Combining a Standard Fischer Esterification Experiment with Stereochemical and Molecular-Modeling Concepts
Clausen, Thomas P.
Journal of Chemical Education, v88 n7 p1007-1009 Jul 2011
The Fisher esterification reaction is ideally suited for the undergraduate organic laboratory because it is easy to carry out and often involves a suitable introduction to basic laboratory techniques including extraction, distillation, and simple spectroscopic (IR and NMR) analyses. Here, a Fisher esterification reaction is described in which the product is also ideally suited for more in-depth analyses of NMR assignments using standard 2D NMR techniques as well as incorporating molecular modeling arguments and the Karplus relationship between torsional angles and vicinal coupling constants to assign [superscript 1]H NMR signals to specific diastereotopic hydrogens. (Contains 2 figures.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A