ERIC Number: EJ937892
Record Type: Journal
Publication Date: 2011-Jul
Abstractor: As Provided
Reference Count: 0
Rapid Association Learning in the Primate Prefrontal Cortex in the Absence of Behavioral Reversals
Cromer, Jason A.; Machon, Michelle; Miller, Earl K.
Journal of Cognitive Neuroscience, v23 n7 p1823-1828 Jul 2011
The PFC plays a central role in our ability to learn arbitrary rules, such as "green means go." Previous experiments from our laboratory have used conditional association learning to show that slow, gradual changes in PFC neural activity mirror monkeys' slow acquisition of associations. These previous experiments required monkeys to repeatedly reverse the cue-saccade associations, an ability known to be PFC-dependent. We aimed to test whether the relationship between PFC neural activity and behavior was due to the reversal requirement, so monkeys were trained to learn several new conditional cue-saccade associations without reversing them. Learning-related changes in PFC activity now appeared earlier and more suddenly in correspondence with similar changes in behavioral improvement. This suggests that learning of conditional associations is linked to PFC activity regardless of whether reversals are required. However, when previous learning does not need to be suppressed, PFC acquires associations more rapidly.
Descriptors: Stimuli, Prior Learning, Brain Hemisphere Functions, Animals, Role, Learning Processes, Associative Learning, Cues, Conditioning, Primatology
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A