ERIC Number: EJ937225
Record Type: Journal
Publication Date: 2011-Sep
Abstractor: As Provided
Reference Count: 0
RSK2 Signaling in Brain Habenula Contributes to Place Aversion Learning
Darcq, Emmanuel; Koebel, Pascale; Del Boca, Carolina; Pannetier, Solange; Kirstetter, Anne-Sophie; Garnier, Jean-Marie; Hanauer, Andre; Befort, Katia; Kieffer, Brigitte L.
Learning & Memory, v18 n9 p574-578 Sep 2011
RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. "Rsk2" gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits. We found that "mrsk2" knockout mice are unable to associate an aversive stimulus with context in a lithium-induced conditioned place aversion task requiring both high-order cognition and emotional processing. Virally mediated shRNA-RSK2 knockdown in the habenula, whose involvement in cognition is receiving increasing attention, also ablated contextual conditioning. RSK2 signaling in the habenula, therefore, is essential for this task. Our study reveals a novel role for RSK2 in cognitive processes and uncovers the critical implication of an intriguing brain structure in place aversion learning.
Descriptors: Brain, Cognitive Processes, Brain Hemisphere Functions, Animals, Cognitive Ability, Stimuli, Genetic Disorders
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A