This review focuses on the families of individuals dually diagnosed with intellectual disability (ID) and comorbid mental health problems. The review examines the impact of caring for individuals with ID and comorbid mental health problems on family well-being, the impact of the family on these individuals, and intervention and support needs of these families. There continues to be a strong need for additional research on and education for families of individuals with ID and comorbid mental health problems. Research limitations and directions for research and practice are also reviewed.