ERIC Number: EJ929049
Record Type: Journal
Publication Date: 2011-Apr
Abstractor: As Provided
Reference Count: 14
Fifteen-Year Follow-Up of Thyroid Status in Adults with Down Syndrome
Prasher, V.; Ninan, S.; Haque, S.
Journal of Intellectual Disability Research, v55 n4 p392-396 Apr 2011
Background: The natural history of thyroid function in adults with Down syndrome is relatively unknown with limited long-term follow-up data. Method: This study investigated annual thyroid function tests in 200 adults with Down syndrome over a 15-year period. Results: For healthy adults with Down syndrome there is a gradual increase in thyroxine and possible gradual decline in thyroid-stimulating hormone with age. The 15-year incidence for definite hypothyroidism remains low and subclinical hypothyroidism is not a precursor for the onset of definite hypothyroidism. Conclusions: The incidence of thyroid dysfunction is markedly less than would be expected from prevalence studies. Subclinical hypothyroidism is not necessarily a precursor to definite hypothyroidism. Prevalence studies have overstated the association between thyroid dysfunction and Down syndrome. Routine screening for adults with Down syndrome who are euthyroid can be reduced to every 5 years rather than the 1-2 years, as is the present policy.
Descriptors: Incidence, Down Syndrome, Followup Studies, Adults, Metabolism, Aging (Individuals), Screening Tests
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A