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ERIC Number: EJ928734
Record Type: Journal
Publication Date: 2011
Pages: 6
Abstractor: As Provided
Reference Count: N/A
ISSN: ISSN-0891-4222
Advanced Parental Ages and Low Birth Weight in Autism Spectrum Disorders--Rates and Effect on Functioning
Ben Itzchak, Esther; Lahat, Eli; Zachor, Ditza A.
Research in Developmental Disabilities: A Multidisciplinary Journal, v32 n5 p1776-1781 Sep-Oct 2011
Objectives: (1) To assess the distribution of parental age and birth weight in a large cohort with autism spectrum disorder (ASD) and to compare them to Israeli national data. (2) To examine possible relationships between these risk factors and functioning. Methods: The study included 529 participants diagnosed with ASD using standardized tests: the Autism Diagnosis Interview-Revised and the Autism Diagnosis Observation Schedule (ADOS). Medical, developmental and familial histories (gender, age, pregnancy and birth information, parental ages) were obtained. Autism severity was assessed using the new ADOS severity scale and adaptive skill using the Vineland Adaptive Behavior Scales. Results: Advanced parental age was associated with ASD. In the older age range the percentages of mothers (35-44 y) and fathers (30-40 y) were significantly higher in the ASD cohort in comparison to the Israeli newborn data. The ASD cohort had significantly higher percentages of low birth weight (less than 2500 g) and very low birth weight (VLBW less than 1500 g) in comparison to the Israeli newborn data. Of these risk factors, only VLBW was associated with lower adaptive functioning. The group with VLBW had lower scores in daily living, socialization and motor skills in comparison to the greater than 1500 g group. Autism severity was not associated with advanced parental age or VLBW. Conclusions: The shift in parental age distribution and birth weight in our ASD cohort suggests that the increase in ASD prevalence in recent years might be associated with novel prenatal insults. An adverse fetal course resulting in VLBW may represent a "second hit" phenomenon, causing a poorer outcome. (Contains 4 tables.)
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Publication Type: Journal Articles; Reports - Research
Education Level: Early Childhood Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: Israel