ERIC Number: EJ928201
Record Type: Journal
Publication Date: 2011-Aug
Abstractor: As Provided
Reference Count: 85
Association of "ADAM10" and "CAMK2A" Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies
Jian, Xue-Qiu; Wang, Ke-Sheng; Wu, Tie-Jian; Hillhouse, Joel J.; Mullersman, Jerald E.
Journal of Abnormal Child Psychology, v39 n6 p773-782 Aug 2011
Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p less than 10[superscript -3]), nine of which were located in known genes, including "ADAM10" (rs383902, p = 0.00036) and "CAMK2A" (rs2053053, p = 0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes ("ADAM10" and "CAMK2A") have been reported to be associated with Alzheimer's disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.
Descriptors: Evidence, Alzheimers Disease, Behavior Disorders, Genetics, Depression (Psychology), Evaluation Methods, Whites, Disabilities, Twins, Family (Sociological Unit), Alcoholism, Science Education
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
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