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ERIC Number: EJ926383
Record Type: Journal
Publication Date: 2011-Jul
Pages: 14
Abstractor: As Provided
Reference Count: 62
ISSN: ISSN-1087-0547
Cerebellar Gray Matter Density in Females with ADHD Combined Type: A Cross-Sectional Voxel-Based Morphometry Study
Almeida Montes, Luis Guillermo; Ricardo-Garcell, Josefina; De la Torre, Lazaro Barajas; Prado Alcantara, Hugo; Martinez Garcia, Reyna Beatriz; Avila Acosta, David; Fernandez Bouzas, Antonio
Journal of Attention Disorders, v15 n5 p368-381 Jul 2011
Background: MRI studies have shown a decreased cerebellum volume in individuals with ADHD. However, most of these studies were conducted with male children, many of whom were medicated with stimulants. As such, unmedicated, non-White girls are underrepresented in such MRI studies. Objective: The aim of the present study was to compare the density of gray matter (GM) in the cerebellar hemisphere between unmedicated, non-White female children, adolescents, and adults diagnosed with ADHD combined type (ADHD-C) and healthy controls. Method: MRIs were performed on 11 Hispanic unmedicated ADHD-C children (6-10 years old), 8 Hispanic adolescents (14-17 years old), 10 Hispanic adults (25-35 years old), and the respective healthy controls. Image processing and statistical analyses were performed by Voxel Based Morphometry using the DARTEL algorithm to improve spatial normalization. Results: Reduced GM density located in the right cerebellar hemisphere was found in female children, adolescents, and adults with ADHD-C. Conclusions: These findings suggest that there is an anatomical abnormality in the right cerebellar hemisphere in unmedicated Hispanic girls with ADHD-C that is present from childhood to adulthood. (Contains 4 tables and 2 figures.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A