Polanyi and Transhumanism both place technologies in pivotal roles in bringing about "Homo sapiens"' species transitions. The question is asked whether Polanyi's emphasis on the role of technology in "Homo sapiens"' rise out of mute beasthood indicates that he might have been inclined to embrace the Transhumanist vision of "Homo sapiens"' technological evolution into a postbiological, techno-cyber species. To answer this question, some of the core commitments of both Transhumanism and Polanyi's postcritical philosophy are examined, especially as they bear on "Homo sapiens"' species transitions. The conclusion reached is that rather than being the next step dictated by the inner logic of Polanyi's thought, Transhumanism is actually the final conclusion of epistemological ideals he spent most of his career denouncing. (Contains 16 notes.)