ERIC Number: EJ921181
Record Type: Journal
Publication Date: 2011-Apr
Abstractor: As Provided
Reference Count: 0
Serotonin- and Training-Induced Dynamic Regulation of CREB2 in "Aplysia"
Liu, Rong-Yu; Shah, Shreyansh; Cleary, Leonard J.; Byrne, John H.
Learning & Memory, v18 n4 p245-249 Apr 2011
Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the "Aplysia" sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found that treatment with 5-HT and behavioral training produce biphasic changes in the expression of CREB2, a transcriptional repressor. An immediate increase in CREB2 protein was followed by a subsequent decrease. The effects of these treatments persist for at least 24 h and are observed in isolated sensory neurons. This study suggests that the dynamics of CREB2 expression could contribute to the consolidation of memory.
Descriptors: Memory, Cognitive Processes, Brain Hemisphere Functions, Genetics, Behavior Modification, Neurological Organization, Metabolism
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A