ERIC Number: EJ920487
Record Type: Journal
Publication Date: 2010-Nov
Abstractor: As Provided
Reference Count: 12
Nature's Anti-Alzheimer's Drug: Isolation and Structure Elucidation of Galantamine from "Leucojum Aestivum"
Halpin, Catherine M.; Reilly, Ciara; Walsh, John J.
Journal of Chemical Education, v87 n11 p1242-1243 Nov 2010
The discovery that galantamine penetrates the blood-brain barrier has led to its clinical use in the treatment of choline-deficiency conditions in the brain, such as Alzheimer's disease. This experiment involves the isolation and structure elucidation of galantamine from "Leucojum aestivum". Isolation of the alkaloid constituents in "L. aestivum" is performed using an acidic solvent extraction system, and flash-column chromatography combined with thin-layer chromatography is used to isolate galantamine in pure form from the extract. During the course of the experiment, the students isolate galantamine with an average recovery of 0.15%. IR, MS, 1D-NMR, and 2D-NMR spectra confirm the structure of galantamine. The experiment can be completed over two, 3-h laboratory sessions and is suitable for upper-level undergraduate students. The experiment acquaints the students with the techniques required to isolate and complete structural elucidation studies on natural products. (Contains 1 figure.)
Descriptors: Undergraduate Students, Alzheimers Disease, Brain, Science Experiments, Science Instruction, Laboratory Experiments, Science Process Skills, Chemistry
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: email@example.com; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Authoring Institution: N/A