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ERIC Number: EJ920483
Record Type: Journal
Publication Date: 2010-Nov
Pages: 3
Abstractor: As Provided
Reference Count: 16
ISSN: ISSN-0021-9584
Synthesis of Aryl-Substituted 2,4-Dinitrophenylamines: Nucleophilic Aromatic Substitution as a Problem-Solving and Collaborative-Learning Approach
Santos, Elvira Santos; Garcia, Irma Cruz Gavilan; Gomez, Eva Florencia Lejarazo; Vilchis-Reyes, Miguel Angel
Journal of Chemical Education, v87 n11 p1230-1232 Nov 2010
A series of experiments based on problem-solving and collaborative-learning pedagogies are described that encourage students to interpret results and draw conclusions from data. Different approaches including parallel library synthesis, solvent variation, and leaving group variation are used to study a nucleophilic aromatic substitution of 1-halo-2,4-dinitrobenzene to obtain aryl-substituted 2,4-dinitrophenylamines. Determining the yield of each reaction in parallel synthesis allows students to make simple structure-reactivity relationships. (Contains 3 figures and 1 scheme.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A