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ERIC Number: EJ918559
Record Type: Journal
Publication Date: 2010-Aug
Pages: 4
Abstractor: As Provided
Reference Count: 20
ISSN: ISSN-0021-9584
Identification and Quantitative Analysis of Acetaminophen, Acetylsalicylic Acid, and Caffeine in Commercial Analgesic Tablets by LC-MS
Fenk, Christopher J.; Hickman, Nicole M.; Fincke, Melissa A.; Motry, Douglas H.; Lavine, Barry
Journal of Chemical Education, v87 n8 p838-841 Aug 2010
An undergraduate LC-MS experiment is described for the identification and quantitative determination of acetaminophen, acetylsalicylic acid, and caffeine in commercial analgesic tablets. This inquiry-based experimental procedure requires minimal sample preparation and provides good analytical results. Students are provided sufficient background information to allow them to independently develop chromatographic separation and analytical-analysis procedures using a liquid chromatograph-mass spectrometer. The experiment can be conducted in two consecutive, 3-h laboratory periods. Students gain experience using state-of-the-art analytical instrumentation that simultaneously provides chromatographic, ultraviolet, and mass spectrometry data. The efficiency of concurrently collecting three different types of experimental data translates into more time for inquiry-based investigation, instructional emphasis on theory, and data manipulation. (Contains 3 notes and 1 figure.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A