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ERIC Number: EJ918438
Record Type: Journal
Publication Date: 2010-Jul
Pages: 3
Abstractor: As Provided
Reference Count: 8
ISSN: ISSN-0021-9584
Ring-Closing Metathesis: An Advanced Guided-Inquiry Experiment for the Organic Laboratory
Schepmann, Hala G.; Mynderse, Michelle
Journal of Chemical Education, v87 n7 p721-723 Jul 2010
The design and implementation of an advanced guided-inquiry experiment for the organic laboratory is described. Grubbs's second-generation catalyst is used to effect the ring-closing metathesis of diethyl diallylmalonate. The reaction is carried out under an inert atmosphere at room temperature and monitored by argentic TLC. The crude reaction is purified with activated carbon, and the product is analyzed using GC-MS and [superscript 1]H, COSY, [superscript 13]C, and DEPT-135 NMR. Additionally, a guided-inquiry approach is employed wherein students design a procedure to determine the influence of various parameters on the progress of the reaction and the purity and yield of the product. Student and instructor assessment of the advantages and challenges of using this approach are included. (Contains 2 tables, 1 figure, 1 scheme and 3 notes.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A