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ERIC Number: EJ918279
Record Type: Journal
Publication Date: 2010-Jun
Pages: 3
Abstractor: As Provided
Reference Count: 30
ISSN: ISSN-0021-9584
Microwave-Assisted Hydantoins Synthesis on Solid Support
Coursindel, Thibault; Martinez, Jean; Parrot, Isabelle
Journal of Chemical Education, v87 n6 p640-642 Jun 2010
In this laboratory activity, students are introduced to a three-step synthesis of hydantoin (imidazolidine-2,4-dione), a moiety that is found in many biologically active compounds. Using a microwave oven and solid-support technology, this synthetic experiment is designed for masters-degree candidates working in organic chemistry or upper-level undergraduate chemistry students interested in solid-phase synthesis. A colorimetric test is used to monitor the reaction on the solid support and analytical techniques such as high-pressure liquid chromatography, mass spectrometry, and nuclear magnetic resonance are used to assess the product purity and yield. (Contains 1 table, 1 figure and 2 schemes.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A