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ERIC Number: EJ918277
Record Type: Journal
Publication Date: 2010-Jun
Pages: 3
Abstractor: As Provided
Reference Count: 27
ISSN: ISSN-0021-9584
Synthesis and Biological Testing of Penicillins: An Investigative Approach to the Undergraduate Teaching Laboratory
Whitaker, Ragnhild D.; Truhlar, Laura M.; Yksel, Deniz; Walt, David R.; Williams, Mark D.
Journal of Chemical Education, v87 n6 p634-636 Jun 2010
The development and implementation of a research-based organic chemistry laboratory experiment is presented. The experiment was designed to simulate a scientific research environment, involve students in critical thinking, and develop the student's ability to analyze and present research-based data. In this experiment, a laboratory class synthesized a library of penicillins, where each student had the freedom to choose which penicillin he or she wanted to synthesize. After the different penicillins were synthesized, the products were tested for antimicrobial activity. All results from the class were compared and penicillins were grouped according to their ability to inhibit bacterial growth. Finally, students evaluated the structure-function relationship between the penicillin's structure and its antimicrobial activity. (Contains 1 figure and 1 scheme.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A