ERIC Number: EJ916933
Record Type: Journal
Publication Date: 2011-Mar
Abstractor: As Provided
Reference Count: 0
Deletion of the GluA1 AMPA Receptor Subunit Alters the Expression of Short-Term Memory
Sanderson, David J.; Sprengel, Rolf; Seeburg, Peter H.; Bannerman, David M.
Learning & Memory, v18 n3 p128-131 Mar 2011
Deletion of the GluA1 AMPA receptor subunit selectively impairs short-term memory for spatial locations. We further investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber. Unconditioned suppression of magazine responding to visual stimuli was measured in wild-type and GluA1 knockout mice. Wild-type mice showed less suppression to a stimulus that had been presented recently than to a stimulus that had not. GluA1 knockout mice, however, showed greater suppression to a recent stimulus than to a nonrecent stimulus. Thus, GluA1 is not necessary for encoding, but affects the way that short-term memory is expressed.
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A