ERIC Number: EJ916890
Record Type: Journal
Publication Date: 2011-Jan
Abstractor: As Provided
Reference Count: 0
PKA and PKC Are Required for Long-Term but Not Short-Term in Vivo Operant Memory in "Aplysia"
Michel, Maximilian; Green, Charity L.; Lyons, Lisa C.
Learning & Memory, v18 n1 p19-23 Jan 2011
We investigated the involvement of PKA and PKC signaling in a negatively reinforced operant learning paradigm in "Aplysia", learning that food is inedible (LFI). In vivo injection of PKA or PKC inhibitors blocked long-term LFI memory formation. Moreover, a persistent phase of PKA activity, although not PKC activity, was necessary for long-term memory. Surprisingly, neither PKA nor PKC activity was required for associative short-term LFI memory. Additionally, PKA and PKC were not required for the retrieval of short- or long-term memory (STM and LTM, respectively). These studies have identified key differences between the mechanisms underlying nonassociative sensitization, operant reward learning, and LFI memory in "Aplysia".
Descriptors: Long Term Memory, Food, Learning, Models, Investigations, Neurological Impairments, Negative Reinforcement, Operant Conditioning
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A