ERIC Number: EJ915151
Record Type: Journal
Publication Date: 2011-Mar
Abstractor: As Provided
Reference Count: 33
Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample
Parr, Jeremy R.; Le Couteur, Ann; Baird, Gillian; Rutter, Michael; Pickles, Andrew; Fombonne, Eric; Bailey, Anthony J.
Journal of Autism and Developmental Disorders, v41 n3 p332-340 Mar 2011
The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself.
Descriptors: Autism, Child Development, Pervasive Developmental Disorders, Siblings, Family Influence, Developmental Disabilities, Cognitive Ability, Neurological Impairments
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A