In August 2005, Hurricane Katrina, the worst natural disaster in the history of the United States, forced the fall semester closure of Tulane University in New Orleans, Louisiana. In the aftermath of this unprecedented storm, the Tulane leadership set forth a plan for renewal to secure the survival, recovery, and sustainability of the institution, which propelled the campus community into mission-critical focus. The university's historic reopening was in January 2006. This chapter describes the strategic thinking, process, and development of Tulane University's Renewal Plan, which was created in response to Hurricane Katrina.