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ERIC Number: EJ913389
Record Type: Journal
Publication Date: 2010-Apr
Pages: 3
Abstractor: As Provided
Reference Count: 40
ISSN: ISSN-0021-9584
Enzymatic Resolution and Separation of Secondary Alcohols Based on Fatty Esters as Acylating Agents
Monteiro, Carlos M.; Afonso, Carlos A. M.; Lourenco, Nuno M. T.
Journal of Chemical Education, v87 n4 p423-425 Apr 2010
The enzymatic resolution of "rac"-1-phenylethanol using ethyl myristate as acylating agent and solvent and "Candida antarctica" lipase B (CAL-B) as biocatalyst was demonstrated with catalyst and medium reuse. Both enantiomers of 1-phenylethanol were isolated by sequential enzymatic reactions and product distillations. From the first enzymatic reaction, ("S")-1-phenylethanol was isolated with a 41% yield and 80% enantiomeric excess, and from the second enzymatic reaction, ("R")-1-phenylethanol was isolated with a 56% yield and 63% enantiomeric excess. (Contains 2 figures and 1 note.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A