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ERIC Number: EJ912249
Record Type: Journal
Publication Date: 2011-Feb
Pages: 6
Abstractor: As Provided
Reference Count: 28
ISSN: ISSN-0162-3257
Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome
Yuhas, Jennifer; Cordeiro, Lisa; Tassone, Flora; Ballinger, Elizabeth; Schneider, Andrea; Long, James M.; Ornitz, Edward M.; Hessl, David
Journal of Autism and Developmental Disorders, v41 n2 p248-253 Feb 2011
Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p less than 0.002) and FXS-A (p less than 0.003) groups had impaired PPI. The FXS+A (p less than 0.01) and FXS-A (p less than 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating. (Contains 3 tables and 4 figures.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A