ERIC Number: EJ910253
Record Type: Journal
Publication Date: 2010-Dec
Abstractor: As Provided
Reference Count: 0
Protein Kinase M[Zeta] Is Essential for the Induction and Maintenance of Dopamine-Induced Long-Term Potentiation in Apical CA1 Dendrites
Navakkode, Sheeja; Sajikumar, Sreedharan; Sacktor, Todd Charlton; Frey, Julietta U.
Learning & Memory, v17 n12 p605-611 Dec 2010
Dopaminergic D1/D5-receptor-mediated processes are important for certain forms of memory as well as for a cellular model of memory, hippocampal long-term potentiation (LTP) in the CA1 region of the hippocampus. D1/D5-receptor function is required for the induction of the protein synthesis-dependent maintenance of CA1-LTP (L-LTP) through activation of the cAMP/PKA-pathway. In earlier studies we had reported a synergistic interaction of D1/D5-receptor function and N-methyl-D-aspartate (NMDA)-receptors for L-LTP. Furthermore, we have found the requirement of the atypical protein kinase C isoform, protein kinase M[zeta] (PKM[zeta]) for conventional electrically induced L-LTP, in which PKM[zeta] has been identified as a LTP-specific plasticity-related protein (PRP) in apical CA1-dendrites. Here, we investigated whether the dopaminergic pathway activates PKM[zeta]. We found that application of dopamine (DA) evokes a protein synthesis-dependent LTP that requires synergistic NMDA-receptor activation and protein synthesis in apical CA1-dendrites. We identified PKM[zeta] as a DA-induced PRP, which exerted its action at activated synaptic inputs by processes of synaptic tagging.
Descriptors: Maintenance, Memory, Biology, Brain Hemisphere Functions, Drug Use, Cytology, Cognitive Processes
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A