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ERIC Number: EJ904479
Record Type: Journal
Publication Date: 2005-Dec
Pages: 9
Abstractor: As Provided
Reference Count: 118
ISSN: ISSN-1080-4013
Mental Retardation Genes in Drosophila: New Approaches to Understanding and Treating Developmental Brain Disorders
Restifo, Linda L.
Mental Retardation and Developmental Disabilities Research Reviews, v11 n4 p286-294 Dec 2005
"Drosophila melanogaster" is emerging as a valuable genetic model system for the study of mental retardation (MR). MR genes are remarkably similar between humans and fruit flies. Cognitive behavioral assays can detect reductions in learning and memory in flies with mutations in MR genes. Neuroanatomical methods, including some at single-neuron resolution, are helping to reveal the cellular bases of faulty brain development caused by MR gene mutations. "Drosophila fragile X mental retardation 1" ("dfmr1") is the fly counterpart of the human gene whose malfunction causes fragile X syndrome. Research on the fly gene is leading the field in molecular mechanisms of the gene product's biological function and in pharmacological rescue of brain and behavioral phenotypes. Future work holds the promise of using genetic pathway analysis and primary neuronal culture methods in "Drosophila" as tools for drug discovery for a wide range of MR and related disorders. (Contains 1 table and 1 figure.)
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Publication Type: Journal Articles; Reports - Descriptive
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A