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ERIC Number: EJ904443
Record Type: Journal
Publication Date: 2004-Nov
Pages: 12
Abstractor: As Provided
Reference Count: 141
ISSN: ISSN-1080-4013
The Search for Autism Disease Genes
Wassink, Thomas H.; Brzustowicz, Linda M.; Bartlett, Christopher W.; Szatmari, Peter
Mental Retardation and Developmental Disabilities Research Reviews, v10 n4 p272-283 Nov 2004
Autism is a heritable disorder characterized by phenotypic and genetic complexity. This review begins by surveying current linkage, gene association, and cytogenetic studies performed with the goal of identifying autism disease susceptibility variants. Though numerous linkages and associations have been identified, they tend to diminish upon closer examination or attempted replication. The review therefore explores challenges to current methodologies presented by the complexities of autism that might underlie some of the current difficulties, and finishes by describing emerging phenotypic, statistical, and molecular investigational approaches that offer hope of overcoming those challenges. (Contains 1 table and 3 figures.)
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A