ERIC Number: EJ904416
Record Type: Journal
Publication Date: 2004-May
Abstractor: As Provided
Reference Count: 71
Serotonin in Autism and Pediatric Epilepsies
Chugani, Diane C.
Mental Retardation and Developmental Disabilities Research Reviews, v10 n2 p112-116 May 2004
Serotonergic abnormalities have been reported in both autism and epilepsy. This association may provide insights into underlying mechanisms of these disorders because serotonin plays an important neurotrophic role during brain development--and there is evidence for abnormal cortical development in both autism and some forms of epilepsy. This review explores the hypothesis that an early disturbance in the serotonin system affects cortical development and the development of thalamocortical innervation, and is a potential mechanism, common to autism and pediatric epilepsies associated with cortical dysplasia. An argument is made that cortical malformation leads to abnormalities of thalamocortical connectivity, and that serotonin plays a critical role in this process. Finally, a role for altered metabolism of the serotonin precursur, tryptophan, in both epilepsy and autism is discussed.
Descriptors: Epilepsy, Autism, Brain, Metabolism, Neurology, Neurological Impairments, Brain Hemisphere Functions, Children
Wiley-Blackwell. 111 River Street, Hoboken, NJ 07030-5774. Tel: 800-825-7550; Tel: 201-748-6645; Fax: 201-748-6021; e-mail: email@example.com; Web site: http://www3.interscience.wiley.com/browse/?type=JOURNAL
Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A