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ERIC Number: EJ904408
Record Type: Journal
Publication Date: 2004-Feb
Pages: 8
Abstractor: As Provided
Reference Count: 102
ISSN: ISSN-1080-4013
The Fragile X Syndrome: From Molecular Genetics to Neurobiology
Willemsen, Rob; Oostra, Ben A.; Bassell, Gary J.; Dictenberg, Jason
Mental Retardation and Developmental Disabilities Research Reviews, v10 n1 p60-67 Feb 2004
Since the identification of the FMR1 gene basic research has been focused on the molecular characterization of the FMR1 gene product, the fragile X mental retardation protein (FMRP). Recent developments in fragile X research have provided new insights and knowledge about the physiological function of FMRP in the cell and the nerve cell in particular. Currently, compelling evidence suggests a role for FMRP in the transport/translation of dendritically localized mRNAs. In addition, the identification of some of the target mRNAs of FMRP have led to an increased interest in the neurobiology of the syndrome. This review highlights the role of FMRP in dendritic mRNA transport/translation in relation to synaptic plasticity, a molecular mechanism implicated in learning and memory. (Contains 1 figure.)
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A