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ERIC Number: EJ904098
Record Type: Journal
Publication Date: 2007
Pages: 7
Abstractor: As Provided
Reference Count: 93
ISBN: N/A
ISSN: ISSN-1080-4013
Epidemiology of Down Syndrome
Sherman, Stephanie L.; Allen, Emily G.; Bean, Lora H.; Freeman, Sallie B.
Mental Retardation and Developmental Disabilities Research Reviews, v13 n3 p221-227 2007
Down syndrome (DS) is the most commonly identified genetic form of mental retardation and the leading cause of specific birth defects and medical conditions. Traditional epidemiological studies to determine the prevalence, cause, and clinical significance of the syndrome have been conducted over the last 100 years. DS has been estimated to occur in [asymptotically equivalent to]1 in 732 infants in the United States, although there is some evidence that variability in prevalence of estimates exist among racial/ethnic groups. Progress has been made in characterizing the specific types of chromosome errors that lead to DS and in identifying associated factors that increase the risk of chromosome 21 malsegregation, i.e., advanced maternal age and recombination. Studies to examine the variability of the presence of specific DS-associated birth defects and medical conditions provide evidence for genetic and environmental modifiers. Here, we provide a brief survey of studies that address the current state of the field and suggest gaps in research that can soon be filled with new multidisciplinary approaches and technological advances. (Contains 1 table.)
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A