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ERIC Number: EJ904045
Record Type: Journal
Publication Date: 2006
Pages: 8
Abstractor: As Provided
Reference Count: 56
ISSN: ISSN-1080-4013
Etiology of Strokes in Children with Sickle Cell Anemia
DeBaun, Michael R.; Derdeyn, Colin P.; McKinstry, Robert C., III
Mental Retardation and Developmental Disabilities Research Reviews, v12 n3 p192-199 2006
The most devastating complication of sickle cell anemia is cerebral infarction, affecting [approximately]30% of all individuals with sickle cell anemia. Despite being one of the most common causes of stroke in infants and children, the mechanism of cerebral infarction in this population has not been extensively studied and is poorly understood. Multiple, synergistic factors are important in the pathogenesis of stroke including the hemodynamic effects of cerebral arterial occlusive disease, viscosity, chronic and acute anemia and acute medical events. This review focuses on the relationship between these factors in order to provide a foundation for further study of the etiology of strokes in this high-risk population. (Contains 4 figures.)
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: Elementary Secondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A